Methandienone
-
CAS
72-63-9 - Formula C20H28O2
- Half-life 3-6 hours (oral)
- Detection 6 weeks
Clinical Notes
C17alpha-alkylated testosterone with an added 1,2-double bond — oral bioavailability via resistance to hepatic first-pass, at the cost of hepatocellular stress. Rapid onset: serum concentrations peak within 2 h, half-life under 6 h. Split dosing (20 mg morning, 20 mg pre-training) holds steadier curves than single boluses. Aromatisation is significant and proceeds via a distinct pathway (17alpha-methylestradiol) which does not respond predictably to anastrozole — SERM (tamoxifen 10 mg/day) is the better intra-cycle gyno control tool. Classic bloat is methylestradiol water retention, not subcutaneous fluid, and dissipates within 2 weeks of cessation. ALT/AST elevation 2–4x ULN is the norm at 30–50 mg/day x 6 weeks. TUDCA 500 mg/day during oral use is non-optional.
Chemical Identity
| CAS Number |
72-63-9 |
|---|---|
| IUPAC Name | (8S,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one |
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.44 g/mol |
| SMILES |
C[C@]1(O)CC[C@@H]2[C@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@H]3CC[C@]12C |
| InChIKey |
YWIHUEAIAGTQJS-UHFFFAOYSA-N |
| Melting Point | 163-167 °C |
| Solubility | Slightly soluble in water; freely soluble in ethanol |
| Half-life | 3-6 hours (oral) |
Pharmacological Profile
| Anabolic Rating | 210 |
|---|---|
| Androgenic Rating | 60 |
| Aromatisation | High |
| Hepatotoxicity | High |
| Detection Window | 6 weeks |
Known trade names
- Dianabol
- Danabol
- Naposim
- Metanabol
External references
Data sourced from peer-reviewed pharmacological literature and authoritative chemical databases (PubChem, DrugBank, ChEBI). Provided for identification and research reference only — not medical advice.