Oral Steroid

Stanozolol

  • CAS 10418-03-8
  • Formula C21H32N2O
  • Half-life 9 hours (oral) / 24 hours (IM)
  • Detection 2 months
Chemical structure of Stanozolol
PubChem CID 25249 ↗

Clinical Notes

Mechanism, kinetics, and protocol-relevant pharmacology — reviewed by the editorial pharmacology lead.

Heterocyclic DHT derivative — pyrazole fused to the A-ring, blocking 3alpha-HSD metabolism. Crushes SHBG in a dose-responsive manner (documented 40–50% reduction at 50 mg/day oral x 4 weeks), which is the proximate mechanism for its perceived amplification effect on co-administered androgens: bound testosterone is released, free-testosterone fraction rises. The compound itself has modest direct AR activity. Oral form is C17alpha-alkylated with predictable hepatotoxicity. Connective-tissue profile is the clinical liability: tendinopathy and ligament rupture frequency is elevated on stanozolol protocols. Joint lubrication complaint is universal above 40 mg/day and resolves on cessation. Lipid degradation is among the steepest in the oral class; HDL reductions of 50–60% at therapeutic doses are reproducible.

Chemical Identity

CAS Number 10418-03-8
IUPAC Name (1S,3aS,3bR,5aS,10aS,10bS,12aS)-1,10a,12a-trimethyl-2,3,3a,3b,4,5,5a,6,10b,11,12,12a-dodecahydro-1H-cyclopenta[5,6]naphtho[1,2-f]indazol-1-ol
Molecular Formula C21H32N2O
Molecular Weight 328.49 g/mol
SMILES C[C@]1(O)CC[C@@H]2[C@H]3CCC4=CC5=CC=N[NH]5C[C@]4(C)[C@@H]3CC[C@]12C
InChIKey HCNHNBLBDSXWPN-UHFFFAOYSA-N
Melting Point 229-242 °C
Solubility Practically insoluble in water; soluble in dimethylformamide
Half-life 9 hours (oral) / 24 hours (IM)

Pharmacological Profile

Anabolic Rating 320
Androgenic Rating 30
Aromatisation None
Hepatotoxicity High
Detection Window 2 months

Known trade names

  • Winstrol
  • Stromba
  • Stanover

External references

Data sourced from peer-reviewed pharmacological literature and authoritative chemical databases (PubChem, DrugBank, ChEBI). Provided for identification and research reference only — not medical advice.